2-HYDROXYBENZYLAMINE[2-(AMINOMETHYL)PHENOL]
2-Hydroxybenzylamine
CAS: 932-30-9
Molecular Formula: C7H9NO
2-HYDROXYBENZYLAMINE[2-(AMINOMETHYL)PHENOL] - Names and Identifiers
| Name | 2-Hydroxybenzylamine |
| Synonyms | 2-Hydroxybenzylamine 2-(Aminomethyl)phenol Phenol, 2-(aminomethyl)- 2-HydroxybenzeneMethanaMine (2-hydroxyphenyl)methanaminium 2-(3-CHLOROPHENOXY)MALONDIALDEHYDE 2-HYDROXYBENZYLAMINE[2-(AMINOMETHYL)PHENOL] 2-Hydroxybenzylamine, (2-Hydroxyphenyl)methylamine |
| CAS | 932-30-9 |
| EINECS | 213-249-7 |
| InChI | InChI=1/C7H9NO/c8-5-6-3-1-2-4-7(6)9/h1-4,9H,5,8H2/p+1 |
2-HYDROXYBENZYLAMINE[2-(AMINOMETHYL)PHENOL] - Physico-chemical Properties
| Molecular Formula | C7H9NO |
| Molar Mass | 123.15 |
| Density | 1.141±0.06 g/cm3(Predicted) |
| Melting Point | 127 °C |
| Boling Point | 245.0±15.0 °C(Predicted) |
| Flash Point | 102°C |
| Solubility | Chloroform (Slightly), Methanol (Very Slightly, Heated) |
| Vapor Presure | 0.0188mmHg at 25°C |
| Appearance | Solid |
| Color | Beige to Brown |
| pKa | 8.63±0.35(Predicted) |
| Storage Condition | under inert gas (nitrogen or Argon) at 2–8 °C |
| MDL | MFCD00870498 |
2-HYDROXYBENZYLAMINE[2-(AMINOMETHYL)PHENOL] - Risk and Safety
| Hazard Symbols | Xi - Irritant |
| Risk Codes | 36/37/38 - Irritating to eyes, respiratory system and skin. |
| Safety Description | S26 - In case of contact with eyes, rinse immediately with plenty of water and seek medical advice. S37/39 - Wear suitable gloves and eye/face protection |
| WGK Germany | 3 |
| HS Code | 29222990 |
| Hazard Class | IRRITANT |
2-HYDROXYBENZYLAMINE[2-(AMINOMETHYL)PHENOL] - Reference Information
| Introduction | 2-Hydroxybenzylamine (2-Hydroxybenzylamine,2-HOBA), also known as salicylamine, is a potent gamma KA scavenger, clearance of gamma KAs is 980 times faster than the formation of gamma KA protein adducts, thus protecting cells from the harmful effects of gamma KA adducts. |
| biological activity | in vitro studies have demonstrated that 2-HOBA can protect HepG2 cells from h2o2-induced cytotoxicity; the beneficial role of 2-HOBA in oxidative stress-related diseases has also been found in many organs and systems in the body. 2-HOBA administration dose-dependently reduces biomarkers of oxidant damage in nematodes and prolongs lifespan. |
| extraction method | a method for extracting 2-hydroxybenzylamine from tartary buckwheat, comprising the following steps:(1) tartary buckwheat roots, stems and seeds were dried, added to liquid nitrogen for grinding, powder;(2) the powder and deionized water mixed, and adjust the solution pH value of 5.0, then add 0.5% powder weight of mixed enzyme for enzymatic hydrolysis, enzymatic hydrolysis temperature is 25 ℃, enzymatic hydrolysis time is 40min, after the completion of the enzymatic hydrolysis, filter residue is obtained, the mixed enzyme is a mixture of cellulase and pectinase in a weight ratio of 2:1;(3) mixing the filter residue obtained in step (2) with 95% ethanol in a solid-liquid ratio of 1G: 10ml, then the ultrasonic power density is 100W/cm2, the ultrasonic frequency is 30kHz, the extraction temperature is 20 ℃, the extraction time is 30min, Repeat extraction 3 times, filtration, combined extract;(4) The supernatant obtained in step (3) is concentrated under reduced pressure to obtain extract, and 3wt% sodium hydroxide solution is added to the extract to dissolve, filter, (5) adjust the filtrate obtained in step (4) with hydrochloric acid until the pH value of the solution is 3 to obtain the adjustment solution. Under the condition of 20 ℃, at a flow rate of 10BV/h through the NDA-150 resin column to saturated adsorption;(6) to reach saturated adsorption, first 50 deg C, 8wt% sodium hydroxide solution as eluent, the elution was carried out at a flow rate of 2BV/h, and the eluent of 2 times the volume of the column was collected, and then the elution was carried out at a flow rate of 2BV/h with 3wt% sodium hydroxide solution at 50 ℃, collect 1 times the volume of column eluent, Finally, 60 C water was used as the eluent, and the elution was carried out at a flow rate of 2BV/h. The eluent of 1 times the volume of the column was collected, and the three eluents were combined;(7) the combined eluent was concentrated under reduced pressure, the crystals are then isolated by recrystallization from edible alcohol to produce 2-hydroxybenzylamine. |
Last Update：2024-04-09 02:00:12
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View History
2-HYDROXYBENZYLAMINE[2-(AMINOMETHYL)PHENOL]
Ammonium metamolybdate
2- Methyl-4-broMo benzoic acidMethyl ester
ISOPHTHALIC ACID DIALLYL ESTER
亚乙基双油酸酰胺
BUFFERED PEPTONE BROTH
1-azabicyclo(3.2.0)hept-2-ene-2-carboxylicacid,6-(1-hydroxyethyl)-3-((1-(1-im
(S)-2-氨基-3-(6-甲氧基-1H-吲哚-3-基)丙酸甲酯
Einecs 227-185-2
RARECHEM BK PT 0093
Ammonium metamolybdate
2- Methyl-4-broMo benzoic acidMethyl ester
ISOPHTHALIC ACID DIALLYL ESTER
亚乙基双油酸酰胺
BUFFERED PEPTONE BROTH
1-azabicyclo(3.2.0)hept-2-ene-2-carboxylicacid,6-(1-hydroxyethyl)-3-((1-(1-im
(S)-2-氨基-3-(6-甲氧基-1H-吲哚-3-基)丙酸甲酯
Einecs 227-185-2
RARECHEM BK PT 0093